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What is the difference between therapeutic ketosis and Ketonacidosis?

July 30, 2017

Here you have a before picture of me at 57 years old on the western diet and an after picture at 65 years old doing intermittent fasting my wife at the age of 62 on intermittent fasting man dose she look hot.

What is the difference between therapeutic ketosis and Ketonacidosis?

Question can ketone supplements have side effects if not taken properly and are they effective?

Man will never be able to mimic nature

Dr. Peters Attia MD explains the difference between therapeutic ketosis and ketonacidosis

You may have heard from your doctor that ketosis is a life-threatening condition. If so, your doctor is confusing diabetic ketoacidosis (DKA) with nutritional ketosis, or keto-adaptation. First, some semantics. Our body can produce, from fat and some amino acids, three ketone bodies (a “ketone” refers the chemical structure where oxygen is double-bonded to carbon sandwiched between at least 2 other carbons). These ketone bodies we produce are: acetone, acetoacetone, and beta-hydroxybutyrate (B-OHB).

Why do we make ketones? For starters, it’s a vital evolutionary advantage. Our brain can only function with glucose and ketones. Since we can’t store more than about 24 hours worth of glucose, we would all die of hypoglycemia if ever forced to fast for more than 24 hours.

Fortunately, our liver can take fat and select amino acids (the building blocks of proteins) and turn them into ketones, first and foremost to feed our brains. Hence, our body’s ability to produce ketones is required for basic survival.

What is diabetic ketoacidosis? When a diabetic (usually a Type I diabetic, but sometimes this occurs in very late-stage, insulin-dependent, Type II diabetics) fails to receive enough insulin, they go into an effective state of starvation. While they may have all the glucose in the world in their bloodstream, without insulin, they can’t get any into their cells. Hence, they are effectively going into starvation.

The body does what it would do in anyone – it starts to make ketones out of fat and proteins. Here’s the problem: the diabetic patient in this case can’t produce any insulin, so there is no feedback loop and they continue to produce more and more ketones without stopping. By the time ketone levels (specifically, beta-hydroxybutyrate) approach 15 to 25 mM, the resulting pH imbalance leads to profound metabolic derangement and the patient is critically ill.

But this state of metabolic derangement is not actually possible in a person who can produce insulin, even in small amounts. The reason is that a feedback loop prevents the ketone level from getting high enough to cause the change in pH that leads to the cascade of bad problems. A person who is said to be “keto-adapted,” or in a state of nutritional ketosis, generally has beta-hydroxybutyrate levels between about 0.5 and 3.0 mM. This is far less than the levels required to cause harm through acid-base abnormalities.

Keto-adaption is a state, achieved through significant reduction of carbohydrate intake (typically to less than 50 grams per day), where the body changes from relying on glycogen as its main source of energy to relying on fat. Specifically, the brain shifts from being primarily dependent on glucose, to being primarily dependent on beta-hydroxybutyrate. This has nothing to do with what a diabetic patient is experiencing in DKA, but does illustrate how poorly informed and quick to react the medical community is. DKA and nutritional ketosis (or keto-adaptation) have as much in common as a house fire and a fireplace.

Here is another research site typically saying the same as the first site

Ketosis is NOT diabetic ketoacidosis, which is a serious complication of uncontrolled diabetes that occurs when your body produces high levels of blood acids called ketones consider comparing therapeutic ketosis to ketoacidosis to be like comparing a fireplace to a house fire. Fire is a great and useful thing when controlled and in the proper situations, but it also has the potential to become very dangerous if not used properly. Ketones are therapeutic and beneficial when in a certain blood level, but are very dangerous at extremely high levels. In therapeutic ketosis, total blood ketones are in the 0.5-5mM range while in ketoacidosis, blood ketones are typically >20mM. This is a huge difference.

There is no reason to be scared of elevating blood ketones to the levels seen in therapeutic ketosis, but rather this level of ketosis is associated with many health benefits (improvements in metabolic health, weight loss, neuroprotection, etc).

This is actually from a supplement company

Let’s talk about ketone supplements, the question is can taking to many ketone supplements cause ketoacidosis yes it can I will explain So, is it possible to elevate your blood ketones to a dangerous level with a supplement product? Yes, technically it could be done; however, it would require consuming much more than the recommended use in one sitting. On average, one serving of KETO//OS raises blood ketones to approximately 0.7mM. Dangerous elevations in blood ketones are in the range of 15-20mM; however, it is not recommended to exceed 5-6mM for therapeutic purposes. Consuming approximately 7+ servings in one sitting would reach this level in most individuals.

As humans, most of the public will see the benefits of ketones for losing weight thru advertising and all those before and after pictures of people losing tons of weight by taking ketone supplements, so what do they think? More is better, even though it says on the supplement bottle what is safe to take they do not see that they take twice as much and that is a health issue, it can and will cause ketoacidosis, you can die from this.

Your body produces natural ketones for free and once you understand how the hormone insulin cause weight gain and how to control it by doing intermittent fasting your body will produce its own natural ketone, this is the best way to help your body lose that body fat and keep your brain working correctly with no side affects

In conclusion why not use your own bodies natural ketones to help you lose that unwanted body fat by doing intermittent fasting following a protocol, its free plus it is much safer than using a supplement, intermittent fasting is not a diet it is a way of life, if it worked for our ancestors with huge health benefits it will work for us. I want to mention the key to a successful intermittent fasting, it is going to be the type of water you are drinking, you have to change the type of water you are drinking watch this short video it will explain why

Bill & Emily Mabry 6A
Wellness Coach/Strength and Conditioning Coach/CMHS
Free Ebook


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